NF-KB signaling pathway-manipulated dendritic cells
AssigneeFriedrich-Alexander-Universität Erlangen-Nürnberg
InventorsKatrin Birkholz, Jan Dörrie, Niels Schaft, Gerold Schuler, Reinhard Voll, Isabell Pfeiffer
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Abstract
The invention relates to dendritic cells, the NFκB signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.
Claims12
A method for treating infectious diseases or cancer in a patient comprising administering a composition comprising dendritic cells to the patient, wherein the dendritic cells comprise an NFκB signaling pathway that has been manipulated by RNA transfection with one or more nucleotide sequences encoding at least one mutant signal transducing protein of the NFκB signaling pathway, wherein the mutant signal transducing protein of the NFκB signaling pathway is a constitutively active IKKα mutant comprising the amino acid residues of SEQ ID NO:2 or IKKβ mutant comprising the amino acid residues of SEQ ID NO:5.
Dependencies are inferred from the claim text.