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US 12,152,226 B2Granted
Cell culture bottle
AssigneeGreen Elephant Biotech GmbH
InventorJoel Eichmann
Life of this patent
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Abstract
The invention relates to a cell culture bottle for adherent cells (e.g. human mesenchymal stem cells), comprising: a vessel; an internal cylinder, which has an internal Archimedes screw; an internal central tube, through which liquid can flow; and at least one wall arranged around the central tube. This arrangement provides an enlarged inner surface for the growth of the cells and for the reliable mixing of the fluid. The cell culture bottle is formed as a single piece and can be simply and economically produced as a disposable device by means of additive manufacturing.
Claims11
A cell-culture bottle comprising
- a vessel comprising three subregions:
- a base region, a lid region and a cylinder region arranged therebetween,
- an Archimedes' screw arranged internally in the cylinder region of the vessel and having a central tube which is arranged along the central axis of said Archimedes' screw and through which liquid is flowable,
- at least one wall which is arranged concentrically around the central tube and which extends over the entire cylinder region of the vessel,
- wherein the cell-culture bottle is formed as one piece and wherein the central tube is designed such that it has a first opening on the outer side of the vessel in the lid region and has a second opening inside the vessel on a bottom side of the cylinder region and wherein the Archimedes' screw is integrally connected to the cylinder region of the vessel and to the at least one wall, wherein the Archimedes' screw and the at least one wall are arranged such that a fluid can pass along the Archimedes' screw from the bottom side of the cylinder region into the lid region of the vessel upon rotation of the cell-culture bottle.
2 more elements
Dependencies are inferred from the claim text.