LHRH-platinum conjugates for treating reproductive cancers
AssigneeEastern Kentucky University
InventorsMargaret Ndinguri, Lindsay Cormier
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Abstract
The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors.
Claims17
A method for delivering a cytotoxic chemotherapeutic agent to a cell that expresses a lutenizing hormone releasing hormone (LHRH) receptor comprising administering to the cell a compound comprised of:
- a LHRH or analog thereof;
- a cytotoxic platinum chemotherapeutic agent;
- and
- a linker, wherein the linker comprises malonate;
- wherein the LHRH or analog thereof is covalently bonded to the cytotoxic platinum chemotherapeutic agent utilizing the linker and further wherein the LHRH analog is selected from the group consisting of [DLys6]-LHRH, [D-Trp6]-LHRH, [D-Ala6]-LHRH, [Gln8]-LHRH, antide, gonadorelin, leuprolide, leuprorelin, histerlin, buserelin, or triptorelin.
A method for delivering a cytotoxic chemotherapeutic agent to cells in a subject that express lutenizing hormone releasing hormone (LHRH) receptor, the method comprising administering to a subject a compound comprised of:
- a LHRH or analog thereof;
- a cytotoxic platinum chemotherapeutic agent;
- and
- a linker, wherein the linker comprises malonate;
- wherein the LHRH or analog thereof is covalently bonded to the cytotoxic platinum chemotherapeutic agent utilizing the linker and further wherein the LHRH analog is selected from the group consisting of [DLys6]-LHRH, [D-Trp6]-LHRH, [D-Ala6]-LHRH, [Gln8]-LHRH, antide, gonadorelin, leuprolide, leuprorelin, histerlin, buserelin, or triptorelin.
Dependencies are inferred from the claim text.