Binding moieties for biofilm remediation
AssigneeTrellis Bioscience, LLC
InventorsLawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
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Abstract
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
Claims18
A monoclonal antibody (mAb) or antigen binding fragment thereof that specifically binds a DNA binding protein II (DNABII), wherein the mAb or antigen binding fragment thereof comprises:
- a heavy chain variable region (SEQ ID NO:1) and a light chain variable region (SEQ ID NO:
- 2) of TRL1068;
- a heavy chain variable region (SEQ ID NO:21) and a light chain variable region (SEQ ID NO:
- 22) of TRL1330;
- or,
- a heavy chain variable region (SEQ ID NO:25) and a light chain variable region (SEQ ID NO:
- 26) of TRL1337.
A monoclonal antibody (mAb) that specifically binds a DNA binding protein II (DNABII), the antibody comprising:
- a heavy chain variable region of (SEQ ID NO:1) and a light chain variable region (SEQ ID NO:
- 2) of TRL1068;
- a heavy chain variable region of (SEQ ID NO:21) and a light chain variable region (SEQ ID NO:
- 22) of TRL1330;
- or,
- a heavy chain variable region of (SEQ ID NO:25) and a light chain variable region (SEQ ID NO:
- 26) of TRL1337;
- and
- wherein the mAb is an Fv antibody, a bispecific antibody, a chimeric antibody, or a complete antibody and wherein the complete antibody comprises generic constant regions heterologous to the variable regions thereof.
A monoclonal antibody (mAb) that specifically binds a DNA binding protein II (DNABII), wherein (i) the mAb is an Fv antibody, a bispecific antibody, a chimeric antibody, or a complete antibody, wherein (ii) the mAb comprises a heavy chain variable region of (SEQ ID NO:1) and a light chain variable region (SEQ ID NO:
- 2) of TRL1068, and wherein (iii) the complete antibody comprises generic constant regions heterologous to the variable regions thereof.
Dependencies are inferred from the claim text.