Process for making a pharmaceutical compound
AssigneeAdeptio Pharmaceuticals Limited
InventorsKishor Bapu Gavhane, Nitin Punjaji Lad, Ramakrishna Guduru, Sunit Ramesh Kulkarni
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Abstract
This invention relates to a novel process for making dihydrotetrabenazines, and in particular (+)-α-dihydrotetrabenazine, novel synthetic intermediates for use in the process and processes for making the intermediates.
Claims18
A process for the preparation of a compound of the formula (5)
- which process comprises the reaction of a compound of the formula (4):
- with allyl zinc bromide.
A process for the preparation of N-(1-(2-(2-chloroethyl)-4, 5-dimethoxyphenyl) but-3-en-1-yl)-2-methylpropane-2-sulfinamide, wherein the 1-position of the but-3-en-1-yl moiety in the N-(1-(2-(2-chloroethyl)-4, 5-dimethoxyphenyl) but-3-en-1-yl)-2-methylpropane-2-sulfinamide has an (R) stereochemical configuration;
- and the 2-methylpropane-2-sulfinamide moiety in the (E)-N-(2-(2-chloroethyl)-4, 5-dimethoxybenzylidene)-2-methylpropane-2-sulfinamide has an (S) stereochemical configuration;
- which process comprises the reaction of (S)-(E)-N-(2-(2-chloroethyl)-4, 5-dimethoxybenzylidene)-2-methylpropane-2-sulfinamide with allyl zinc bromide.
Dependencies are inferred from the claim text.