Small molecule compounds having naphthylamine structure and application thereof

A compound having a structure represented by Formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof,

• wherein:
• Z is
• R1 is hydrogen or C1˜6 alkyl;
• R2 is hydrogen, C1˜6 alkyl, three to six-membered cycloalkyl, three to six-membered epoxyalkyl, phenyl or C1˜6 alkyl substituted phenyl;
• R3 is
• wherein R3-1 is hydrogen, hydroxyl, C1˜6 alkyl, C1˜6 alkoxy, three to six-membered cycloalkyl, three to six-membered epoxyalkyl, amino, C1˜6 amido, —CH2C(O)R3-2, —CH2C(O)OR3-2 or —CH2C(O)N(R3-2R3-2a),
• R3-2 and R3-2a are each independently hydrogen, C1˜6 alkyl or three to six-membered cycloalkyl,
• Ar is phenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl, 8 to 10-membered fused bicyclic heteroaryl, phenyl with at least one hydrogen atom substituted by R3-3, naphthyl with at least one hydrogen atom substituted by R3-3, 5- or 6-membered monocyclic heteroaryl with at least one hydrogen atom substituted by R3-3 or 8 to 10-membered fused bicyclic heteroaryl with at least one hydrogen atom substituted by R3-3, the R3-3 is hydrogen, halogen, C1˜6 alkyl, three to six-membered cycloalkyl, hydroxyl, C1˜6 alkoxy, three to six-membered epoxyalkyl, C1˜6 haloalkyl, C2˜6 alkenyl, C2˜6 alkynyl, —N(R3-3aR3-3b) or phenyl,
• R3-3a and R3-3b are each independently hydrogen, C1˜6 alkyl or three to six-membered cycloalkyl;
• R4 is
• wherein R4-1 is phenyl, naphthyl, phenyl with at least one hydrogen atom substituted by R4-11, 5- or 6-membered monocyclic heteroaryl, 5- or 6-membered monocyclic heteroaryl with at least one hydrogen atom substituted by R4-11 or 8 to 10-membered fused bicyclic heteroaryl, or 8- to 10-membered fused bicyclic heteroaryl with at least one hydrogen atom substituted by R4-11, and the R4-11 is hydrogen, halogen, nitro, nitrile group, hydroxyl, C1˜6 alkyl, three to six-membered cycloalkyl, C1˜6 alkoxy, —N(R4-1aR4-1b), phenyl, C1˜6 haloalkyl, C1˜6 haloalkoxy, —C(O)OR4-12, —C(O)R4-12, —C(O)N(R4-1aR4-1b), —S(O)2R4-12, —S(O)R4-12, —OC(O)R4-12, —OC(O)OR4-12 or
• R4-12, R4-1a and R4-1b are each independently hydrogen, C1˜6 alkyl, three to six-membered cycloalkyl, C2˜6 alkenyl, C2˜6 alkynyl, C1˜6 alkyl with at least one hydrogen substituted by halogen, C2˜6 alkenyl with at least one hydrogen substituted by halogen, three to six-membered cycloalkyl with at least one hydrogen substituted by halogen, or C2˜6 alkynyl with at least one hydrogen substituted by halogen, and R4-1a and R4-1b can be bonded to each other to form a ring,
• R4-2 is hydrogen, C1˜6 alkyl or three to six-membered cycloalkyl, or when R2 is C1˜6 alkyl, R4-2 and R2 are bonded to form a 4˜8 membered ring,
• R4-3 is hydrogen, C1˜6 alkyl or C1˜6 alkoxy;
• and
• the number of R5 is 0˜5, and when the number of R5 is not 0, each R5 is independently selected from halogen, nitro, nitrile group, —N+(R5-1)3, C1˜6 haloalkyl, —C(O)OR5-1, —C(O)R5-1, —C(O)N(R5-1R5-1a), —S(O)2R5-1, —S(O)R5-1, —S(O)2N(R5-1R5-1a), —S(O)N(R5-1R5-1a), —N═C(R5-1R5-1a), hydroxyl, C1˜6 alkyl, phenyl, phenyl with at least one hydrogen substituted by R5-1, C1˜6 alkoxy, —N(R5-1R5-1a), —N(R5-1)C(O)R5-1a, —N(R5-1)C(O)OR5-1a, —N(R5-1)C(O)N(R5-1aR5-1b), —OC(O)R5-1, —OC(O)OR5-1, —OC(O)N(R5-1R5-1a) and —SR5-1, wherein R5-1, R5-1a and R5-1b are each independently hydrogen, C1˜6 alkyl, C2˜6 alkenyl, C2˜6 alkynyl, C1˜6 alkyl with at least one hydrogen substituted by halogen, C2˜6 alkenyl with at least one hydrogen substituted by halogen, or C2˜6 alkynyl with at least one hydrogen substituted by halogen,
• with the proviso that:
• the compound of Formula (I) is not
• and
• when R1 and R2 are hydrogen, R4 is
• Z is
• and the number of R5 is 0, then R3 is not —CH2COOCH2CH3.