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US 12,151,033 B2Granted
Foam compositions, foam matrices and methods
AssigneeCovalon Technologies Inc.
InventorsVyacheslav Dudnyk, Mirzo Kanoatov, Valerio Ditizio
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Abstract
Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.
Claims14
A method for making a matrix, the method comprising:
- foaming a composition comprising a biomolecule and a biocompatible polymer, wherein the biomolecule is selected from the group consisting of gelatin, collagen, elastin, and combinations thereof, and the biocompatible polymer is selected from the group consisting of polyethylene glycol, poly-L-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate, pectin, cellulose, carboxymethylcellulose and mixtures thereof;
- crosslinking the foamed composition;
- and
- drying the composition, to prepare the matrix, wherein the biomolecule and biocompatible polymer are evenly distributed throughout the matrix;
- wherein the matrix is a dried, cross-linked foam;
- wherein the biomolecule is present in an amount of from about 40% to about 80% (w/w) by the weight of said matrix;
- and wherein the matrix is non-lyophilized and has an absorption capacity of from about 20 times to about 50 times a dry weight of the matrix.
4 more elements
Dependencies are inferred from the claim text.