PEG lipids and uses thereof
AssigneeModernaTX, Inc.
InventorsEdward J. Hennessy, Kerry Benenato
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Abstract
The present disclosure in part provides compounds (i.e., PEG lipids) which are useful in pharmaceutical compositions, cosmetic compositions, and drug delivery systems, e.g, for use in lipid nanoparticle (LNP) formulations. The present disclosure also provides LNP formulations comprising PEG lipids described herein, and methods of using the same. For example, the LNPs provided herein are useful for the delivery of an agent (e.g, therapeutic agent) to a subject. The PEG lipids and LNPs provided herein, in certain embodiments, exhibit increased PEG shedding compared to existing PEG lipids and LNP formulations.
Claims10
A lipid nanoparticle (LNP) comprising a PEG lipid of Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- L1 is a bond, optionally substituted C1-3 alkylene, optionally substituted C1-3 heteroalkylene, optionally substituted C2-3 alkenylene, or optionally substituted C2-3 alkynylene;
- R1 is optionally substituted C5-30 alkyl, optionally substituted C5-30 alkenyl, or optionally substituted C5-30 alkynyl;
- RO is hydrogen, optionally substituted alkyl, optionally substituted acyl, or an oxygen protecting group;
- and
- r is an integer from 2 to 100, inclusive.
Dependencies are inferred from the claim text.