Composition for inhibiting release of neurotransmitters
AssigneeLG Household & Health Care Ltd.
InventorsWoo-Seon Hwang, Yun-Sun Kim, Mu-Hyun Jin, Nae-Gyu Kang
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Abstract
The present disclosure relates to a composition for inhibiting neurotransmitter secretion by inhibiting membrane potential generation of the nerve. The composition of the present disclosure has a synergistic effect related to inhibition of SNARE complex formation, and thereby, it can prevent active secretion of neurotransmitters, and thus can reduce muscle contraction to improve skin wrinkles.
Claims9
A method for inhibiting neurotransmitter secretion, comprising applying a composition comprising a combination of (i) a Zanthoxylum piperitum fruit extract and (ii) a SNARE formation inhibitor as an active ingredient to a subject in need thereof,
- wherein the SNARE formation inhibitor is argireline, botulinum neurotoxin type A light chain (BoNT/A LC), or a mixture thereof, and
- wherein a weight of the comprised Zanthoxylum piperitum fruit extract is equal to or greater than a weight of the SNARE formation inhibitor.
Dependencies are inferred from the claim text.