Therapeutic combinations to treat red blood cell disorders

A method of treating sickle cell disease, diabetic red blood cell dysfunction, or thalassemia comprising administering at least one agent increasing High Density Lipoprotein (HDL) activity in combination with at least one liposoluble antioxidant selected from a xanthophyll, lutein, zeaxanthin, meso-zeaxanthin, astaxanthin, beta-cryptoxanthin, a tocopherol isomer or derivative thereof selected from alpha-, beta-, gamma- and delta-tocopherol and a tocotrienol isomer or derivative thereof selected from alpha-, beta-, gamma- and delta-tocotrienol or a mixture of said at least one agent increasing HDL activity and said at least one antioxidant to a subject having sickle cell disease, diabetic red blood cell dysfunction, or thalassemia, wherein said at least one agent increasing HDL activity is a Cholesteryl Ester Transfer Protein (CETP) modulator selected from dalcetrapib and anacetrapib and said at least one agent increasing HDL activity and said at least one liposoluble antioxidant are administered without additional active agents.