Mesenchymal stem cell and use thereof for treatment of muscle injury and muscle-associated diseases
AssigneeExostem Biotec Ltd.
InventorsChaya Brodie, Shlomit Brodie
Life of this patent
Estimating the term…
Abstract
Isolated cells of a mixed character, possessing a mesenchymal stem cell phenotype and a muscle cell phenotype, as well as extracellular vesicles secreted from same, pharmaceutical compositions comprising same, and methods of treatment comprising administering same, are provided. Further, methods of increasing engrafiment of foreign cells by co-administering same are provided.
Claims20
A method of treating or ameliorating a muscle-associated disease or damage in a subject in need thereof, wherein said muscle-associated disease or damage is selected from muscular dystrophy, spinal cord injury, muscle wasting, cardiac muscle injury, fibrosis, cachexia, amyotrophic lateral sclerosis (ALS) and skeletal muscle injury, the method comprising administering a pharmaceutical composition comprising a therapeutically effective amount of:
- a. chorionic placenta or umbilical cord MSCs, extracellular vesicles from said chorionic placenta or umbilical cord MSCs or both;
- and
- b. a muscle cell or an MSC transdifferentiated toward a muscle cell phenotype, extracellular vesicles from said muscle cell or said transdifferentiated MSC, or both;
- to said subject, thereby treating, preventing or ameliorating said muscle-associated disease or damage.
A method of reducing muscle fibrosis or inducing muscle regeneration in a subject in need thereof, the method comprising administering a pharmaceutical composition comprising a therapeutically effective amount of:
- a. chorionic placenta or umbilical cord MSCs, extracellular vesicles from said chorionic placenta or umbilical cord MSCs or both;
- and
- b. a muscle cell or an MSC transdifferentiated toward a muscle cell phenotype, extracellular vesicles from said muscle cell or said transdifferentiated MSC, or both;
- to said subject, thereby reducing muscle fibrosis or inducing muscle regeneration.
A method of increasing muscle cell engraftment into a subject in need thereof, the method comprising administering a pharmaceutical composition comprising a therapeutically effective amount of:
- a. chorionic placenta or umbilical cord MSCs, extracellular vesicles from said chorionic placenta or umbilical cord MSCs or both;
- and
- b. a muscle cell or an MSC transdifferentiated toward a muscle cell phenotype;
- to said subject, thereby increasing muscle cell engraftment into a subject.
Dependencies are inferred from the claim text.