# US 12,150,954 B1 · Composition and method for reducing risk of hypocalcemia in periparturient ruminant animals > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,150,954 B1 - Document ID: US12150954B1 - Status: Granted - Kind: B1 - Application number: 18/618,702 - Filed: 2024-03-27 - Granted: 2024-11-26 - Earliest claimed: 2023-11-21 - Assignees: Protekta Inc. - Applicants: Protekta Inc. - Inventors: Morten Jakobsen; Lasse Jakobsen; Rod Martin; Meghan Connelly; Patrick Hoffman - Web page: https://patentgrep.com/patent/US12150954B1 ## CPC - A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} - A23K 20/20: Inorganic substances, e.g. oligoelements - A23K 20/22: Compounds of alkali metals - A23K 20/24: Compounds of alkaline earth metals, e.g. magnesium - A23K 20/26: Compounds containing phosphorus - A23K 50/10: for ruminants - A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration} - A61P 3/14: for calcium homeostasis (vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23K: FODDER - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A method of reducing risk of periparturient hypocalcemia in a periparturient ruminant animal involves: measuring blood phosphorus concentration in the animal; and, administering a composition containing a phosphorus-binding compound and optionally, a pharmacologically acceptable carrier to the animal during at least part of a prepartum period of the animal, the composition having an effective amount of the phosphorus-binding compound to control the blood phosphorus concentration in a range of 1.5-3.5 mg P per dL of blood in the animal. ## Claims ### Claim 1 A method of reducing risk of periparturient hypocalcemia in at least one periparturient ruminant animal, the method comprising the steps of: a) measuring a blood phosphorus (P) concentration in the at least one periparturient ruminant animal; and b) after step a) perorally administering to the periparturient ruminant animal during at least part of a prepartum period of the periparturient ruminant animal a composition comprising: i. an effective amount of a phosphorus-binding compound to control the blood phosphorus concentration in a range of 1.5-3.5 mg P per dL of blood in the periparturient ruminant animal, wherein the phosphorus-binding compound comprises an aluminum compound; and ii. a pharmacologically acceptable carrier. ### Claim 2 (depends on 1) The method of claim 1, wherein the blood phosphorus concentration of step b) is controlled to be in a range of 1.8-3.0 mg P per dL of blood. ### Claim 3 (depends on 1) The method of claim 1, wherein the blood phosphorus concentration of step b) is controlled to be in a range of 2.0-2.5 mg P per dL of blood. ### Claim 4 (depends on 1) The method of claim 1, wherein: if the blood phosphorus concentration is below the range, administration rate of the composition of step b) is decreased or the composition is reformulated to decrease the amount of the compound and/or increase the phosphorus to aluminum ratio; and, if the blood phosphorus concentration is above the range, administration rate of the composition of step b) is increased or the composition is reformulated to increase the amount of the compound relative to phosphorus in the composition and/or decrease the phosphorus to aluminum ratio, so that the blood phosphorus concentration is brought into the range. ### Claim 5 (depends on 1) The method of claim 1, wherein the measuring of step a) is done periodically. ### Claim 6 (depends on 1) The method of claim 1, wherein the phosphorus-binding compound of step b) reduces bioavailability of the phosphorus in a digestive system of the periparturient ruminant animal. ### Claim 7 (depends on 1) The method of claim 1, wherein the periparturient ruminant animal is a dairy cow. ### Claim 8 (depends on 1) The method of claim 1, wherein the composition of step b) is a feed composition, and the pharmacologically acceptable carrier comprises one or more animal feed components other than the phosphorus-binding compound. ### Claim 9 (depends on 1) The method of claim 1, wherein: a) the composition is a feed composition; b) the pharmacologically acceptable carrier comprises one or more animal feed components other than the phosphorus-binding compound; and c) the feed composition provides a dietary phosphorus (P) to aluminum (Al) weight ratio in a range of 0.7:1 to 1.4:1. ### Claim 10 (depends on 9) The method of claim 9, wherein the weight ratio is in a range of 0.8:1 to 1.1:1. ### Claim 11 (depends on 1) The method of claim 1, wherein the aluminum compound comprises an aluminosilicate, aluminum sulfate, aluminum chloride, aluminum ammonium sulfate, aluminum potassium sulfate, aluminum sodium sulfate, aluminum calcium silicate, aluminum hydroxide, aluminum bromide, aluminum iodide, aluminum nitrate, aluminum carbonate, a hydrate thereof or any mixture thereof. ### Claim 12 (depends on 1) The method of claim 1, wherein the aluminum compound comprises aluminum sulfate, aluminum chloride, aluminum hydroxide, a hydrate thereof or any mixture thereof. ### Claim 13 A method of inducing a transient phase hypophosphatemia in a periparturient ruminant animal, the method comprising the steps of: a) measuring a blood phosphorus (P) concentration in the at least one periparturient ruminant animal; and b) after step a) perorally administering to the periparturient ruminant animal during at least part of a prepartum period of the periparturient ruminant animal a composition comprising: i. an effective amount of a phosphorus-binding compound to control the blood phosphorus concentration in the periparturient ruminant animal in a range of 1.5-3.5 mg P per dL of blood, wherein the phosphorus binding compound comprises an aluminum compound; and ii. a pharmacologically acceptable carrier.