Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof
AssigneeSovida Solutions Ltd.
InventorsHanns-Eberhard Erle, Johannes Holzmeister, Anne Abriat
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Abstract
Disclosed herein are compositions that include nicotinamide adenine dinucleotide (NAD), precursors thereof, derivatives thereof, or mixtures thereof encapsulated in a liposome, wherein the compositions exhibit enhanced chemical, physical, and/or microbial storage stability at a variety of storage temperatures. In certain embodiments, the compositions are stable and have positive permeability and senescence results. Also disclosed herein are methods for preparing such compositions and methods of using such compositions.
Claims5
A method of administration comprising topically administering to a subject in need thereof a composition comprising (i) a liposome comprising lecithin;
- (ii) a solvent comprising a combination of water, glycerin and pentylene glycol;
- (iii) tocopherol;
- (iv) a pH adjusting agent;
- and (v) an active agent encapsulated in the liposome, wherein the active agent comprises nicotinamide adenine dinucleotide (NAD+), wherein based on total weight of the composition:
- the NAD+ is in an amount from about 0.5 wt % to about 15 wt %,
- the lecithin is in an amount from about 0.5 wt % to about 15%,
- the water is in an amount from about 5% to about 40%,
- the glycerol is in an amount from about 30% to about 80%,
- the pentylene glycol is in an amount from about 0.5 wt % to about 15%,
- the tocopherol is in an amount up to about 0.5 wt %, and
- the pH adjuster is in an effective amount to adjust the pH of the composition to a range from about 4 to about 9.
Dependencies are inferred from the claim text.