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US 12,146,885 B2Granted
Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening
AssigneeLyfstone B.V.
InventorsStein Lian, Jarle Mikalsen, Eric Bendiksen, Anders Einung Hansen
Life of this patent
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Abstract
Implant related risk of revision not caused by an infection or metal on metal reaction can be addressed by the methods provided herein, including diagnosing implant related risk of revision, use of kits for such diagnostic purposes and compositions for use in the treatment of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction.
Claims20
A method of treating a joint pathology, the method comprising:
- detecting a level of calprotectin of at least 4 mg/l in a biological sample from a human subject, wherein the biological sample is synovial fluid collected at the site of a joint;
- and
- administering to the human subject an anti-inflammatory drug therapy if the detected level of calprotectin is 4 mg/l to 50 mg/l, or administering joint surgery if the detected level of calprotectin is ≥50 mg/l;
- wherein the calprotectin in the biological sample is a secreted polypeptide and not an intracellular polypeptide of intact cells present in the biological sample.
1 more element
A method of treating a joint pathology in a subject, the method comprising:
- administering a therapy to a subject, wherein the subject has been identified as being at risk of a joint pathology by having a level of calprotectin of at least 4 mg/l in a synovial fluid sample collected from a site of a joint in the subject,
- wherein the therapy is an anti-inflammatory drug therapy if the detected level of calprotectin is 4 mg/l to 50 mg/l, or wherein the therapy is joint surgery if the detected level of calprotectin is ≥50 mg/l, and
- wherein the calprotectin in the biological sample is a secreted polypeptide and not an intracellular polypeptide of intact cells present in the biological sample.
Dependencies are inferred from the claim text.