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US 12,146,875 B2Granted
Methods for categorizing and treating subjects having cystic fibrosis (CF) and at risk for severe pulmonary exacerbation
AssigneeNational Jewish Health
InventorMilene Saavedra
Life of this patent
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Abstract
The present invention is related to novel methods for categorizing and treating a population of subjects having cystic fibrosis (CF) and who are at risk of severe pulmonary exacerbation comprising detecting the expression levels of genes in a gene panel consisting of TLR2, ADAM9, PLXND1, CD163, CD36, CD64, CSPG2, IL32, HPSE, and HCA112 and aggressively treating the subject when the expression levels of the genes from the gene panel predicts the subject is at risk for severe pulmonary exacerbation.
Claims5
A method of treating a subject having cystic fibrosis and at risk for severe pulmonary exacerbation, the method comprising
- a. obtaining a whole blood sample from the subject;
- b. detecting the mRNA expression level of each of the following genes in a gene panel consisting of:
- TLR2, ADAM9, PLXND1, CD163, CD36, CD64, CSPG2, IL32, HPSE, and HCA112;
- c. determining the subject's risk for severe pulmonary exacerbation by calculating a risk score of mild, moderate or severe pulmonary exacerbation based on the subject's combined mRNA expression level of the genes from step (b), wherein the subject's calculated risk score correlates to a risk score for mild, moderate or severe pulmonary exacerbation;
- and
- d. treating the subject determined to be at risk for severe exacerbation with treatments effective for treating severe pulmonary exacerbations.
3 more elements
Dependencies are inferred from the claim text.