Endothelial cell factors and methods thereof
AssigneeChildren's Medical Center Corporation
InventorsLeonard I. Zon, Elliott J. Hagedorn
Life of this patent
Estimating the term…
Abstract
The technology described herein relates to compositions and methods of generating endothelial niche cells. Embodiments of the technology described herein comprise compositions, kits, vectors, and methods related to generating or engineering endothelial niche cells. One aspect comprises a method to generate/engineer endothelial niche cells, comprising expressing one or more transcription factors in an endothelial cell, wherein the one or more transcription factors are from the Ets family, the Sox family, and/or the Nuclear Hormone (NHR) family.
Claims12
A method to generate endothelial niche cells, comprising expressing one or more exogenous transcription factors in an endothelial cell, wherein the one or more transcription factors include at least one transcription factor from the Ets family, at least one transcription factor from the Sox family, and at least one transcription factor from the Nuclear Hormone Receptor family.
Dependencies are inferred from the claim text.