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US 12,145,963 B2Granted
Phenothiazine derivatives and uses thereof
AssigneeCamp4 Therapeutics Corporation
InventorsDavid A. Bumcrot, Alfica Sehgal, Donald L. Hertzog
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Abstract
The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).
Claims1
A compound of formula (II):
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is selected from the group consisting of hydrogen, —OH, and C1-6alkoxy;
- R2 is C1-6alkyl substituted with one or more substituents each independently selected from the group consisting of —OH, C1-6alkoxy, —C(O)NRaRb, —C(O)Rc, —C(O)ORd, S(O)2C1-6alkyl, and S(O)2NRaRb;
- R3 is hydrogen or C1-6alkyl;
- Ra, Rb, Rc, and Rd are each independently hydrogen or C1-6alkyl;
- n is 1 or 2;
- and
- m is selected from the group consisting of 1, 2, or 3.
5 more elements
Dependencies are inferred from the claim text.