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US 12,145,913 B2Granted
Inhibition of Olig2 activity
AssigneeCurtana Pharmaceuticals, Inc.
InventorsGraham Beaton, Stanton F. McHardy, Ambrosio Lopez, Jr., Bismarck Campos, Hua-Yu Leo Wang
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Abstract
Described herein are compounds and pharmaceutical compositions of phenyl-pyrimidinyl-urea derivatives, which inhibit the activity of Olig2. An example of a phenyl-pyrimidinyl-urea derivative has the following structure: Also described herein are methods using the Olig2 inhibitors for treating cancer and other diseases. The Olig2 inhibitors may be used to treat glioblastoma.
Claims6
A compound having the structure of:
- or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.