Preparation of chiral primary amine from asymmetric reductive amination of simple ketone catalyzed by ruthenium-diphosphine catalyst

A method for preparing a chiral primary amine, comprising:

• in an argon atmosphere, adding a ketone compound, a ammonium salt, a ruthenium-diphosphine catalyst and an organic solvent to a reaction flask;
• placing the reaction flask into an autoclave, followed by hydrogen injection, wherein a pressure of the hydrogen is 10-200 atm;
• performing an oil-bath stirring treatment on the autoclave at 20-160° C. for 0.5-240 h to generate an intermediate;
• cooling the autoclave to a room temperature and releasing the hydrogen;
• adding a protonic acid into the reaction flask for reaction at 80° C. for 6.0 h to obtain a reaction mixture;
• and
• subjecting the reaction mixture to neutralizing, washing, extracting and drying to obtain the chiral primary amine.