Back to results
US 12,145,875 B2Granted
Polyphosphate glass microspheres, methods of making and uses thereof
AssigneeDalhousie University
InventorsMark Filiaggi, Arash Momeni
Life of this patent
Estimating the term…
Abstract
Polyphosphate glass microspheres (PGMs) are prepared using a polyphosphate coacervate. PGMs can be loaded with various therapeutic agents and can be used for various medical and dental procedures and treatments.
Claims8
A method for preparing spherical phosphate glass microspheres, the method comprising:
- (a) providing a phosphate polymer comprising a linear polymer of phosphate having a degree of polymerization ranging from about 3 to about 20,000;
- (b) preparing a coacervate comprising admixing an aqueous solution of the phosphate polymer with metal cations thereby forming a polyphosphate coacervate the metal cations selected from the group consisting of:
- Ag+, Zn2+, Tc4+, Gd3+, Ga3+, La3+, Ca2+, Cu2+, Mg2+, Sr2+, Fe2+, Y3+, Ba2+ or combinations thereof;
- (c) admixing the polyphosphate coacervate with a water immiscible organic solvent to transform the polyphosphate coacervate into spherical particles;
- (d) solidifying the spherical particles using a solvent extraction process, to form the polyphosphate glass microspheres;
- and;
- (e) dehydrating the polyphosphate glass microspheres by admixing the polyphosphate glass microspheres of step (d) with a water immiscible solvent.
4 more elements
Dependencies are inferred from the claim text.