Multimodal adsorption medium with multimodal ligands, method for the preparation and use thereof
AssigneeSartorius Stedim Biotech GmbH
InventorsLukas Kupracz, Florian Taft, Louis Villain, Kornelia Kuper
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Abstract
The present invention relates to a multimodal adsorption medium, in particular a multimodal chromatography medium, a method for its production, as well as use of the adsorption medium according to the invention or an adsorption medium produced according to the invention for the purification of biomolecules.
Claims6
A multimodal adsorption medium having a functional surface, comprising a polymeric carrier material with polymeric spacer elements bound to the surface thereof, to which multimodal ligands of the following structure -G-(CO2H)n are covalently bonded via an —X—(C═O) group,
- where T denotes the polymeric carrier material with the polymeric spacer elements bound to the surface thereof,
- X denotes an —NH— moiety on the polymeric spacer element,
- the structure -G-(CO2H)n is selected from the group consisting of (3), (4), (6) to (14) and (15):
- and
- wherein the polymeric spacer elements are selected from the group consisting of polyallylamine, polyvinyladine, poly(4-aminostyrene), poly-L-lysine, poly(N-methylvinylamine), poly(N-methylallylamine) and poly(oleylamine).
Dependencies are inferred from the claim text.