US 12,145,121 B1Granted

Flow control mechanism for high-throughput oligonucleotide synthesis

OwnerBruce Erickson, Marshall Henryinventors

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Abstract

An improved apparatus for oligonucleotide synthesis, that has four or more synthesis vessels, each synthesis vessel having a waste emitting end, a synthesis plate holding the four or more synthesis vessels, a drain block located below and coupled to the synthesis plate, a sealing device in contact with the synthesis plate and the drain block, one or more waste collection reservoirs located inside of the drain block, one or more equilibration holes, each equilibration hole penetrating the exterior of the drain block and the waste collection reservoir(s), one or more waste tubes connected to the waste collection reservoir(s), each waste tube comprising a waste valve. The sealing device may have one or more sealing blocks, and the equilibration holes may be located in the sealing blocks in lieu of in the drain block. Each equilibration hole may be coupled to a solenoid or flow control valve.

Claims12

Dependent claims

An apparatus comprising:

four or more synthesis vessels, each of the four or more synthesis vessels having a waste emitting end;
a synthesis plate holding the four or more synthesis vessels, the synthesis plate having a bottom surface with grooves;
a drain block located below and operably coupled to the synthesis plate;
a sealing device disposed between and in contact with the synthesis plate and the drain block, the sealing device having holes to allow flow of material from the four or more synthesis vessels to the drain block;
one or more waste collection reservoirs located inside of the drain block;
one or more equilibration holes, each of the one or more equilibration holes penetrating an exterior of the drain block and one of the one or more waste collection reservoirs, the equilibration holes located above the waste emitting end of the four or more synthesis vessels;
one or more waste tubes, each of the one or more waste tubes operably connected to the one or more waste collection reservoirs.

4 more elements

Dependencies are inferred from the claim text.