Probiotics and probiotic compositions for regulating body weight
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsAbhinav Prakash Acharya, Steven R. Little
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Abstract
The present disclosure relates to probiotics and probiotic compositions having modified energy metabolisms (e.g., modifying, metabolizing, or storing energy molecules, e.g., lipids, before the energy molecules are absorbed by a host subject), and thus modulating the absorption of the energy molecules by the host subject. The present disclosure also relates to methods of making such probiotics and probiotic compositions. The present disclosure further relates to methods of regulating (e.g., maintaining or reducing) body weight in a subject (e.g., a subject having a healthy BMI, a subject having an overweight BMI, a subject having an obese BMI), using the probiotics and probiotic compositions disclosed herein.
Claims15
A method of making a probiotic composition comprising:
- (a) obtaining a saliva sample or a stool sample from a mammalian subject;
- (b) isolating bacteria from the saliva or the stool sample;
- (c) subjecting the isolated bacteria to a stress-based directed evolution to generate probiotic bacteria therefrom, wherein the stress-based directed evolution comprises culturing the bacteria in increasing lipid concentrations, wherein the probiotic bacteria have an increased fatty acid metabolism and/or increased lipase activity as compared to the bacteria not subjected to the stress-based directed evolution;
- and
- (d) incorporating the probiotic bacteria to a composition to produce the probiotic composition.
Dependencies are inferred from the claim text.