Biomedical patches with aligned fibers

A method of manufacturing an electrospun graft material for facilitating wound healing, the method comprising:

• depositing via electrospinning a first polymer composition and a second polymer composition to form a biomedical wound matrix comprising a first polymeric scaffold and a second polymeric scaffold, the first polymer composition being different from the second polymer composition,
• the first polymeric scaffold comprising a first structure of fibers having electrospun nanofibers, the first structure of fibers comprising a plurality of randomly oriented fiber sections, the first structure of fibers configured to promote cell growth upon application of the biomedical wound matrix to a tissue,
• the second polymeric scaffold comprising a second structure of fibers having electrospun nanofibers, the second structure of fibers comprising a plurality of substantially straight fiber sections and a plurality of randomly oriented fiber sections,
• wherein one or more of the plurality of substantially straight fiber sections transition into one or more of the plurality of randomly oriented fiber sections of the second structure of fibers, wherein one or more of the plurality of randomly oriented fiber section is overlaid on one or more of the substantially straight fiber sections,
• the second structure of fibers configured to provide structural reinforcement to the first polymeric scaffold,
• wherein the biomedical wound matrix is sufficiently flexible to facilitate application of the biomedical wound matrix to uneven surfaces of the tissue, and
• wherein the biomedical wound matrix is sufficiently flexible to enable movement of the biomedical wound matrix with the tissue;
• and
• customizing the biomedical wound matrix to a particular size to obtain the electrospun graft material.