Peptides and compositions for inhibiting hair growth
AssigneeRodan & Fields, LLC
InventorsKathryn P. Rodan, Kathy A. Fields, John Simon Craw
Life of this patent
Estimating the term…
Abstract
Synthetic peptides which have been shown to be FGF18 agonists are described. Topical compositions for decreasing, eliminating, or suppressing hair growth are disclosed herein. Methods for reducing hair growth, improving the appearance of skin, kits, and related cosmetic formulations are also provided herein.
Claims20
A topical composition comprising an effective amount of a fibroblast growth factor 18 (FGF18) agonist peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:
- 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, DRV, and combinations thereof, and a cosmetically acceptable excipient, wherein the topical composition is formulated as a lotion, cream, serum, spray, mousse, aerosol, emulsion, cake, ointment, gel, paste, patch, pencil, towelette, mask, stick, foam, elixir, oil-in-water emulsion (O/W), water-in-oil (W/O) emulsion, microemulsion, or concentrate.
A topical composition comprising:
- (i) an effective amount of a fibroblast growth factor 18 (FGF18) agonist peptide consisting of:
- (a) an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:
- 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, DRV, and combinations thereof;
- and
- (b) a protection group linked at the N-terminus of the amino acid sequence, wherein the protection group is selected from the group consisting of:
- an acetyl group, a fluorenyl methoxy carbonyl group, a formyl group, a palmitoyl group, a myristyl group, a stearyl group, a linoleate group, a polyethylene glycol (PEG), and other cosmetically acceptable protecting groups;
- and
- (ii) a cosmetically acceptable excipient, wherein the topical composition is formulated as a lotion, cream, serum, spray, mousse, aerosol, emulsion, cake, ointment, gel, paste, patch, pencil, towelette, mask, stick, foam, elixir, oil-in-water emulsion (O/W), water-in-oil (W/O) emulsion, microemulsion, or concentrate.
A method for decreasing, or eliminating hair growth in a subject comprising topically administering to a target location on the subject a topical composition comprising an effective amount of one or more fibroblast growth factor 18 (FGF18) agonist peptides consisting of amino acid sequences selected from the group consisting of SEQ ID NO:1, SEQ ID NO:
- 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, DRV, and combinations thereof, and a cosmetically acceptable excipient, wherein the topical composition is formulated as a lotion, cream, serum, spray, mousse, aerosol, emulsion, cake, ointment, gel, paste, patch, pencil, towelette, mask, stick, foam, elixir, oil-in-water emulsion (O/W), water-in-oil (W/O) emulsion, microemulsion, or concentrate.
Dependencies are inferred from the claim text.