Composition and methods for tumor imaging and treatment
AssigneeThe University of Chicago
InventorsRaymond E. Moellering, Jae Won Chang
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Abstract
Radioisotope-labeled small molecule activity-based probes that target the cancer associated serine hydrolase neutral cholesterol ester hydrolase 1 (NCEH1) are described. The probes can undergo a reaction with the NCEH1, resulting in covalent bonding of a portion of the probe molecule to the NCEH1. Also described are methods of labeling NCEH1 in biological samples, such as cells or tissue, and methods of visualizing tumors using the radioisotope-labeled NCEH1 probes as tracer compounds, either alone or in combination with assessing the efficacy of a cancer treatment or potential cancer treatment.
Claims11
A compound having a structure of the formula:
A method of labeling neutral cholesterol ester hydrolase 1 (NCEH1), wherein the method comprises contacting a sample with a compound having a structure of the formula:
A method of visualizing a tumor in a subject, wherein the method comprises:
- (a) administering to a subject having or suspected of having a tumor a tracer compound having the formula:
- (b) detecting radioactivity of the tracer compound, thereby visualizing a tumor or the edges thereof when a tumor is present in said subject.
Dependencies are inferred from the claim text.