Cholesterol reducing compositions and methods of use thereof
OwnerDouglas Kenny, Hera Vlamakis +3inventors
InventorsDouglas Kenny, Hera Vlamakis, Ramnik Xavier, Emily Balskus, Damian Plichta
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Abstract
Microbes expressing cholesterol oxidoreductase (COR) proteins, methods of engineering the microbes expressing COR proteins, compositions and methods of using the microbes are provided.
Claims25
A non-naturally occurring microbe engineered to express one or more homologs of a cholesterol oxidoreductase (COR) protein, wherein the one or more homologs of the COR protein has at least 95% amino acid sequence identity to one or more sequences in Table 1 or has at least 95% amino acid sequence identity with ECOP170 (SEQ ID NO:44).
A method of reducing serum total cholesterol and/or triglycerides in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a non-naturally occurring microbe engineered to express one or more cholesterol oxidoreductase (COR) proteins or a homolog thereof, wherein the one or more COR proteins or homologs thereof has at least 95% amino acid sequence identity to one or more sequences in Table 1 or has at least 95% amino acid sequence identity with ECOP170 (SEQ ID NO-44).
Dependencies are inferred from the claim text.