Methods, compositions, and devices for supplying dietary fatty acid needs
AssigneeAlcresta Therapeutics, Inc.
InventorsAlexey L. Margolin, Robert Gallotto, Bhami Shenoy
Life of this patent
Estimating the term…
Abstract
Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.
Claims26
A method of preparing a nutritional formula prior to ingestion by a subject, the method comprising:
- exposing at least one of milk, infant formula, or enteral formula comprising triglycerides to immobilized lipase to at least partially hydrolyze the triglycerides within the at least one of milk, infant formula, or enteral formula,
- wherein the at least one of milk, infant formula, or enteral formula is exposed to the immobilized lipase for no more than 60 minutes, prior to ingestion by the subject, and
- wherein the immobilized lipase does not form a part of the nutritional formula.
A method of preparing a nutritional formula comprising fats in the form of monoglycerides and free fatty acids prior to ingestion by a subject, the method comprising:
- exposing at least one of milk, infant formula, or enteral formula comprising triglycerides to an immobilized lipase to form the nutritional formula;
- and
- separating the immobilized lipase and the at least one of milk, infant formula, or enteral formula after the exposing step, wherein the nutritional formula is ready for ingestion by the subject once the at least one of milk, infant formula, or enteral formula is exposed to the immobilized lipase and the immobilized lipase and the at least one of milk, infant formula, or enteral formula are separated,
- wherein the at least one of milk, infant formula, or enteral formula is exposed to the immobilized lipase for no more than 60 minutes, prior to ingestion by the subject.
A method of preparing a nutritional formula comprising fats in the form of monoglycerides and free fatty acids prior to ingestion by a subject, the method comprising:
- exposing at least one of milk, infant formula, or enteral formula comprising triglycerides to an immobilized lipase for no more than 30 minutes prior to separating the immobilized lipase and the at least one of milk, infant formula, or enteral formula, wherein the immobilized lipase is immobilized within a device, and wherein the device includes a mesh for allowing movement of the at least one of milk, infant formula, or enteral formula into and out of the device, while preventing the immobilized lipase from flowing out of the device.
A method of preparing a nutritional formula comprising fats in the form of monoglycerides and free fatty acids prior to ingestion by a subject, the method comprising:
- exposing at least one of milk, infant formula, or enteral formula comprising triglycerides to an immobilized lipase to form the nutritional formula, wherein the resulting nutritional formula comprises more free fatty acids than monoglycerides,
- wherein the at least one of milk, infant formula, or enteral formula is exposed to the immobilized lipase for no more than 60 minutes, prior to ingestion by the subject,
- wherein the immobilized lipase is immobilized within a device, and
- wherein the device includes a mesh for allowing movement of the at least one of milk, infant formula, or enteral formula into and out of the device, while preventing the immobilized lipase from flowing out of the device.
Dependencies are inferred from the claim text.