Muramyl peptide derivatives
AssigneesBharat Biotech International Limited, Council of Scientific and Industrial Research
InventorsKrishna Murthy Ella, Ganneru Brunda, Halmuthur Mahabalarao Sampath Kumar, Paturu Rama Subba Reddy
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Abstract
The invention is directed to Muramyl Dipeptide (MDP) derivative compounds of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof: wherein, R can be a linear or branched alkyl, an aryl, a substituted aryl, or an alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are particularly useful as adjuvants in vaccines.
Claims20
A compound comprising a muramyl dipeptide of the formula:
- wherein R is a linear alkyl, aryl, substituted aryl or alkoxy alkyl with 4 or more carbons.
A compound comprising a muramyl dipeptide with a formula selected from the group consisting of the following chemical structures:
A compound comprising a muramyl dipeptide of the formula:
- wherein R is a branched alkyl, aryl, substituted aryl or alkoxy alkyl with 3 or more carbons.
Dependencies are inferred from the claim text.