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US 12,134,610 B2Granted
Somatostatin subtype-2 receptor (SST2R) targeted therapeutics and uses thereof
AssigneeCrinetics Pharmaceuticals, Inc.
InventorsJian Zhao, Yunfei Zhu, Mi Chen
Life of this patent
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Abstract
Described herein are somatostatin subtype-2 receptor (SST2R) targeted therapeutics that target tumor cells expressing SST2R and their use in the treatment of cancer.
Claims29
A compound that has the structure of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- A is —N(H)— or —O—;
- Ra is hydrogen or C1-C6alkyl;
- R2 is hydrogen or C1-C6alkyl;
- R6 is chloro or —C(═O)NH2;
- L is -L1-L2-;
- L1 is an optional spacer;
- and
- L2 is an optional linker;
- wherein at least one of L1 or L2 is present;
- and
- Rd is a payload moiety comprising a chemotherapeutic agent.
9 more elements
A compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.