Quinoline cGAS antagonist compounds

A compound, wherein the compound is of formula I*:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is an optionally substituted imidazole, pyrazole, pyrrole, furan, or pyridine;
• R2 is —NRR5,
• each R3 is independently halogen, —OMe, —OEt, —NR2, or —SR;
• Ring B1 is substituted phenyl;
• Ring B2 is a 4- to 7-membered saturated or partially unsaturated carbocyclic or heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• or a 5- to 6-membered heteroaryl ring having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic;
• benzyl;
• phenyl;
• a 4- to 7-membered saturated or partially unsaturated carbocyclic or heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• and a 5- to 6-membered heteroaryl ring having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• R5 is —(CH2)2-4OH, —(CH2)2-4O(CH2)1-5CO2H, —(CH2)2-4O(CH2)1-5CO2C1-4alkyl, —(CH2)0-3CH(CH2OH)2, —(CH2)2-4OC1-4alkyl, —(CR2)0-5CO2R, —(CR2)0-5CONR2, —(CR2)0-4C(O)NR(CR2)0-4CO2R, —(CR2)0-4C(O)NR(CR2)0-4CONR2, —(CR2)0-4NRC(O)R, —(CR2)0-4SO3R, —(CR2)0-4SO2NR2, —(CR2)0-4 OSO2NR2, —(CR2)0-4NRSO2R, —(CR2)0-4NRSO2OR, —(CR2)0-4OP(OR)2, —(CR2)0-4OP(O)(OR)2, —(CR2)0-4P(O)(OR)2, —(CR2)0-4OP(O)(H)OR;
• each R6 is independently halogen, —CN, —COR, —(CR2)0-4CO2R, —(CR2)0-4CONR2, —OR, —(CR2)1-4OR, —NR2, —(CR2) 1-4NR2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, —SR, —SO2R, —S(O)R, —(CR2)0-4SO3R, —(CR2)0-4SO2NR2, —(CR2)0-4OSO2NR2, —(CR2)0-4NRSO2R, —(CR2)0-4NRSO2OR, —(CR2)0-4OP(OR)2, —(CR2)0-4OP(O)(OR)2, —(CR2)0-4P(O)(OR)2, —(CR2)0-4OP(O)(H)OR, —B(OR)2, or RB,
• RB and RC, independently, are an optionally substituted group selected from C1-6 aliphatic;
• phenyl;
• a 4- to 10-membered saturated or partially unsaturated monocyclic or bicyclic carbocyclic or heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• and a 5- to 6-membered heteroaryl ring having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each Ra is independently H or C1-6alkyl;
• each m is 1, 2, 3, or 4;
• n is 1, 2, 3, or 4;
• q is 0, 1, or 2.