Compounds for inhibiting LY6K and methods of using same
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorGeeta Upadhyay
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Abstract
The present technology relates to compounds that inhibit human Ly6K and homologs thereof. Also disclosed are methods of using such compounds to: inhibit activity of a Ly6K protein in a cell; decrease migration, colony formation, and/or proliferation of a cell; modulate expression of a gene in a cell, reduce suppression of the immune response to cancer in a subject, decrease tumorigenic growth of a cancer in a subject, and treat or prevent in a subject a disorder mediated by Ly6K protein.
Claims8
A method for inhibiting Ly6K protein in a subject in need thereof, comprising administering to the subject:
- (i) an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, or
- (ii) an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, or
- (iii) an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, and
- an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof,
- wherein the effective amount is sufficient to lower activity of the Ly6k protein in the subject.
A method for treating a disorder mediated by Ly6K protein in a subject in need thereof, comprising administering to the subject:
- (i) an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, or
- (ii) an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, and
- an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.