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US 12,133,901 B2Granted
PSMA ligand targeted compounds and uses thereof
AssigneeCase Western Reserve University
InventorsJames Basilion, Clemens Burda, Dong Luo, Xinning Wang
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Abstract
Prostate-specific membrane antigen (PSMA) targeted compounds having formula (I), nanoclusters formed thereof, pharmaceutical compositions comprising a plurality of these compounds, and methods for treating and detecting cancers in a subject are described herein.
Claims24
A composition for detecting and/or treating cancer, the composition comprising a plurality of compounds that include formula (I):
- wherein:
- n and n1 are each independently 1, 2, 3, or 4;
- L is an optionally substituted aliphatic or heteroaliphatic linking group;
- B comprises at least one negatively charged amino acid;
- and
- Z has the formula
- wherein Z is directly or indirectly linked to B.
4 more elements
A method for treating prostate cancer comprising:
- (a) administering systemically to a subject with prostate cancer a therapeutically effective amount of a composition, the composition comprising a gold nanocluster, the gold nanocluster including a plurality of compounds having formula (I):
- wherein n and n1 are each independently 1, 2, 3, or 4, L is an optionally substituted aliphatic or heteroaliphatic linking group, B comprises at least one negatively charged amino acid, and
- Z has the formula
- wherein Z is directly or indirectly linked to B;
- and
- (b) irradiating the prostate cancer of the subject, thereby inducing the radiosensitizing effects of the gold nanocluster.
3 more elements
Dependencies are inferred from the claim text.