Methods and compositions to enhance arteriogenesis
AssigneeCal Poly Corporation
InventorsTrevor Cardinal, Vahid Hamzeinejad, Ethan Tietze
Life of this patent
Estimating the term…
Abstract
A method is described for enhancing arteriogenesis in animals with comorbidities commonly found in patients with ischemic disease, and in animals with a genetically-impaired arteriogenesis response. Administration to an animal of satellite derived myoblasts increases maximum diameter of collateral arteries. In embodiments, the animal is an obese animal or an animal having impaired arteriogenesis due to genetic variation causing the phenotype. The administration of such myoblasts to a non-obese animal does not increase maximum diameter of the animal's collateral arteries. Blood flow is increased, and ischemia is decreased. Compositions and kits comprising the myoblasts are also provided.
Claims19
A method of increasing maximum collateral diameter of at least one collateral of an animal, comprising,
- a) administering to said animal satellite cell derived myoblasts;
- and
- b) increasing maximum collateral diameter of said at least one collateral, wherein said animal is obese.
A method of reducing ischemia in an obese animal or animal having a genetic alteration causing impaired arteriogenesis, comprising,
- a) introducing into said animal satellite cell derived myoblasts;
- b) increasing maximum diameter of said at least one collateral, wherein the at least one collateral is a collateral of a peripheral artery;
- and
- c) reducing ischemia in said animal;
- wherein said animal is obese.
A method of treating peripheral artery disease in an animal, the method comprising,
- a) administering to said animal satellite cell derived myoblasts;
- and
- b) increasing maximum collateral diameter of at least one collateral, wherein the at least one collateral is a collateral of a peripheral artery;
- wherein said animal is obese.
Dependencies are inferred from the claim text.