Lipid-like nanocomplexes and uses thereof

A compound having a structure represented by Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein
• A, a hydrophilic head, is selected from:
• wherein:
• Ra and Ra′ are each independently selected from H, C1-C20 alkyl, C3-C20 cycloalkyl, C1-C20 heteroalkyl, C1-C20 heterocycloalkyl, C6 monocyclic aryl, and 5-8 monocyclic heteroaryl;
• and
• Z is selected from a C1-C20 bivalent aliphatic radical and a C1-C20 bivalent heteroaliphatic radical;
• B is
• wherein
• R1 and R2 are each independently at each occurrence a C1-C20 bivalent aliphatic radical;
• R3 and R4 are each independently at each occurrence selected from H and C1-C10 alkyl;
• or, alternatively, R3 and R4, together with the atom to which they are attached, form C3-C10 cycloalkyl;
• R5 is independently at each occurrence selected from C1-C24 alkyl, C2-C24 alkenyl, C2-C24 alkynyl, C3-C24 cycloalkyl, C1-C24 heteroalkyl, C1-C24 heterocycloalkyl, aryl, and heteroaryl;
• W is independently at each occurrence selected from O, S, and Se;
• V is independently at each occurrence selected from a bond, O, S, and Se;
• X is independently at each occurrence selected from
• wherein:
• L1, L2, L3, and L4 are each independently at each occurrence selected from a bond, O, S, and NRc;
• G is independently at each occurrence selected from O, S, and NRd;
• Q is independently at each occurrence selected from ORf, SRg, and NRhRi;
• r and t are each independently at each occurrence an integer from 1 to 6;
• wherein Rc, Rd, Rf, Rg, Rh, and Ri are each independently at each occurrence selected from H, C1-C10 alkyl, C1-C10 heteroalkyl, aryl, and heteroaryl;
• and
• m is 1;
• and
• at least one of W and V is Se.