Protease variants and uses thereof
AssigneeSeismic Therapeutic, Inc.
InventorsNathan Higginson-Scott, Nathan Rollins, Jordan Anderson, Alex Pellerin, Ryan Peckner, Yi Xing, Ivan Mascanfroni, Kevin Lewis Otipoby, Yanfeng Zhou
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Abstract
Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.
Claims25
A polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1303.
A polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1318.
A pharmaceutical composition comprising a polypeptide dimer, wherein the dimer comprises a first polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1303 and a second polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1303.
Dependencies are inferred from the claim text.