Oxysterols and methods of use thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R1 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, or heterocyclyl;
• each of R2a and R2b is independently hydrogen, C1-C6 alkyl, halo, cyano,—ORA, or —NRBRC, or
• R2a and R2b together with the carbon atom to which they are attached form a 3-7 membered ring;
• each of R4a and R4b is independently absent, hydrogen, C1-C6 alkyl, or halo;
• X is —C(RX)2— or —O—, wherein RX is independently hydrogen, halo, or one RX group and R5b are joined to form a double bond;
• Y is —ORY, wherein RY is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRC, or —S(O)2RD;
• each instance of R5a and R5b is independently hydrogen, halo, or C1-C6 alkyl;
• each of R6a and R6b is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or
• R6a and R6b, taken together with the carbon atom to which they are attached, form a 3-6 membered ring;
• or
• R5a and R6a, together with the carbon atoms to which they are attached, form a 3-6-membered ring;
• and
• R7 is absent or hydrogen in the alpha configuration;
• R8 is hydrogen, halo, C1-6alkyl, carbocyclyl, or —ORA;
• represents a single or double bond, wherein when one is a double bond, the other is a single bond;
• wherein when the between —CR7 and —CR4aR4b is a double bond, then one of R4a or R4b is absent;
• and
• when one of the is a double bond, R7 is absent;
• RA is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
• each of RB and RC is independently hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, or taken together with the atom to which they are attached form a 3-7-membered ring;
• and
• RD is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl.