Neuroactive steroids, compositions, and uses thereof
AssigneeSage Therapeutics, Inc.
InventorsRavindra B. Upasani, Boyd L. Harrison, Benny C. Askew, Jean-Cosme Dodart, Francesco G. Salituro, Albert Jean Robichaud
Life of this patent
Estimating the term…
Abstract
Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v), and wherein L1, L2, L3, X1, X2, Y, Rz4, Rz5, Rz6, n, R1, R2, R3a, R3b, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R14, R17, R19, R20, R23a, R23b, and R24 are as defined herein, and pharmaceutical compositions thereof. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions in mammals.
Claims18
A compound of Formula (I-b1), (I-b2) or (I-b3):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- Z is selected from the group consisting of
- R3b is hydrogen;
- R3a is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
- each instance of R2, R11a, and R11b is independently hydrogen or —ORB1, wherein RB1 is hydrogen or substituted or unsubstituted alkyl, or R11a and R11b are joined to form an oxo (═O) group;
- and
- each of R6a and R6b is independently hydrogen, halo, or substituted or unsubstituted alkyl.
Dependencies are inferred from the claim text.