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US 12,129,248 B2Granted
Chromobox protein inhibitors and uses thereof
AssigneeDana-Farber Cancer Institute, Inc.
InventorsJames Bradner, Jun Qi, Alexander Federation, Zoe Jacobson, Anthony Varca
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Abstract
Provided herein are compounds useful as inhibitors of CBX. Also described are pharmaceutical compositions and medical uses of these compounds.
Claims10
A compound having a structure of Formula I or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is
- R2 is H, halo, optionally substituted aryl, or optionally substituted heteroaryl;
- L1 is optionally substituted —C(O)NH-alkylene- or —C(O)NHNCH—;
- and
- A is
3 more elements
A compound selected from
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.