Dry powder drug delivery system and methods
AssigneeMannKind Corporation
InventorsChad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
Life of this patent
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Abstract
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.
Claims21
A dry powder inhalation system, comprising:
- a dry powder for oral inhalation and a dry powder inhaler, wherein the dry powder inhaler comprises:
- a) a first element comprising a mouthpiece;
- b) a second element comprising a cartridge, including, a powder container and a lid;
- and c) at least two rigid air conduits;
- wherein one of the at least two rigid air conduits in a dosing configuration includes a deflector or stem protruding from an undersurface of the lid facing an internal volume of the powder container configured to direct airflow entering the internal volume of the powder container along a pathway that is substantially U-shaped from a direction parallel to the mouthpiece to a substantially downward direction to a direction substantially parallel to the mouthpiece through the dry powder to a direction substantially perpendicular to the mouthpiece to exit the powder container;
- wherein in a containment configuration the dry powder is sealed from the at least two rigid air conduits and from the deflector or stem;
- wherein the powder container comprising a first vertical wall and a second vertical wall parallel and opposed;
- and
- wherein in the dosing configuration the deflector or stem is disposed between the first vertical wall and the second vertical wall.
A dry powder inhalation system comprising:
- a dose of a dry powder medication and a high resistance dry powder inhaler, wherein the high resistance dry powder inhaler comprises:
- a) a first element comprising a mouthpiece;
- and b) at least two rigid air conduits;
- wherein one of the at least two rigid air conduits in a dosing configuration includes a deflector or stem protruding from an undersurface of a lid facing an internal volume of a powder container configured to direct airflow entering the internal volume of the powder container along a pathway that is substantially U-shaped from a direction parallel to the mouthpiece to a substantially downward direction to a direction substantially parallel to the mouthpiece through the dry powder to a direction substantially perpendicular to the mouthpiece to exit the powder container;
- and wherein in a containment configuration the dry powder is sealed from the at least two rigid air conduits and from the deflector or stem;
- wherein the powder container comprises a first vertical wall and a second vertical wall parallel and opposed;
- wherein in the dosing configuration the deflector or stem is disposed between the first vertical wall and the second vertical wall.
A dry powder inhalation system, comprising:
- a dry powder and a dry powder inhaler, wherein the dry powder inhaler comprises:
- a) a first element comprising a mouthpiece;
- b) a second element comprising a cartridge, including, a powder container and a lid;
- and c) at least two rigid air conduits;
- wherein one of the at least two rigid air conduits in a dosing configuration includes a deflector or stem protruding from an undersurface of the lid configured to direct airflow entering the internal volume of the powder container along a pathway that is substantially U-shaped;
- and
- wherein in a containment configuration the dry powder is sealed from the at least two rigid air conduits and from the deflector or stem.
Dependencies are inferred from the claim text.