Glyco-metal-organic frameworks-based hepatic targeted therapeutic drug and preparation method thereof

A method for preparing a drug for targeted treatment of liver diseases, wherein the drug has a structure having components A, B, C and D;

• wherein A is selected from one or more of the same or different chemotherapeutic drugs:
• doxorubicin, sorafenib and 5-fluorouracil;
• B is metal-organic frameworks (MOFs) with a photosensitizer as a linking arm;
• C is a linking group, and the linking group is-CO-PEG-CO-;
• D is galactose or a monosaccharide or oligosaccharide molecule containing a galactosamine residue;
• wherein the MOFs are used as a carrier to load the chemotherapeutic drugs, and a surface of the MOFs is linked to the galactose or the monosaccharide or oligosaccharide containing the galactosamine residue through the -OCO-PEG-COO linking group;
• wherein the MOFs are selected from PCN-224 and PCN-222;
• wherein the method comprises the following steps:
• (1) preparing chemotherapeutic drug@-PCN-224:
• dispersing ZrOCl2·8H2O, TCPP and benzoic acid in an organic solvent;
• mixing the materials uniformly;
• adding a chemotherapeutic drug to form a mixed system;
• performing a reaction at 80-100° C.;
• then performing solid-liquid separation to collect precipitate;
• washing and drying the precipitate to obtain chemotherapeutic drug@PCN-224;
• wherein the chemotherapeutic drug is selected from one or more of the following:
• doxorubicin, sorafenib, and 5-fluorouracil;
• (2) dispersing the chemotherapeutic drug@PCN-224 obtained in step (1) and COOH-PEG-COOH in water to form a mixed solution;
• performing a reaction at room temperature;
• after the reaction, performing solid-liquid separation to collect precipitate;
• washing and drying the precipitate to obtain carboxyl-modified chemotherapeutic drug@PCN-224;
• and
• (3) dissolving the carboxyl-modified chemotherapeutic drug@PCN-224 obtained in step (2), amino-modified galactose, and a condensing agent in water;
• performing a reaction at room temperature;
• after the reaction, performing solid-liquid separation to collect precipitate;
• washing and drying the precipitate to obtain chemotherapeutic drug@Gal-PCN-224.