Back to results
US 12,123,875 B2Granted
Antigen analogue for calibration of immunometric diagnostic assays
AssigneeOrtho-Clinical Diagnostics, Inc.
InventorsBrett Hirsch, Jian Zheng, Stephen Daggett
Life of this patent
Estimating the term…
Abstract
An antigen with an increased half-life is provided for the formulation of more stable and consistent clinical diagnostic immunoassay controls and calibrators. An antigen analogue comprises a first and a second polypeptide which is identical or similar to corresponding terminal amino acid sequences of an antigen. The first and second polypeptides are connected with a PEG chain. Also provided are methods of calibrating assays using a compound disclosed herein.
Claims9
A compound of formula (I):
- X—O—(CH2CH2O)n—Y (I)
- wherein
- (i) X is RVEWLRKKLQDVHN (SEQ ID NO:1) and Y is EDNVLVESH (SEQ ID NO:2),
- (ii) X is DLETSGLQEQRN (SEQ ID NO:3) and Y is PLQESPRPT (SEQ ID NO:4), or
- (iii) X is GYYRRATRRIRGGDGKMKDLS (SEQ ID NO:5) and Y is QRQKKQQTVTLLPAADLDDFS (SEQ ID NO:6), and
- n is an integer between 1 and 30.
3 more elements
Dependencies are inferred from the claim text.