LC system and method with column backflushing
AssigneeRoche Diagnostics Operations, Inc.
InventorsAndreas Leinenbach, Aart Pieter van Doorn
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Abstract
A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.
Claims14
A liquid chromatographic (LC) system comprising
- at least one HPLC column,
- a downstream valve fluidically connected to the at least one HPLC column and fluidically connectable to a detector via a valve-to-detector conduit, wherein the at least one HPLC column is fluidically connectable to the valve-to-detector conduit via the downstream valve,
- characterized in that
- the LC system further comprises a pump fluidically connected to the downstream valve and fluidically connectable to the at least one HPLC column via the downstream valve in order to backflush and thereby clean the at least one HPLC column,
- wherein the at least one HPLC column comprises at least two HPLC columns, and
- wherein the at least two HPLC columns are alternately fluidically connectable to the valve-to-detector conduit via the downstream valve.
An automated LC method comprising fluidically connecting at least one HPLC column to a downstream valve in order to fluidically connect the at least one HPLC column to a detector via a valve-to-detector conduit, the method further comprising fluidically connecting a pump to the at least one HPLC column via the downstream valve in order to backflush and thereby clean the at least one HPLC column and fluidically connecting the pump to the valve-to-detector conduit via the downstream valve in order to wash the valve-to-detector conduit.
Dependencies are inferred from the claim text.