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US 12,123,046 B2Granted
Fusion protein of flavin adenine dinucleotide-glucose dehydrogenase and cytochrome molecule
AssigneesUltizyme International Ltd., I-Sens, Inc.
InventorsKoji Sode, Youngjea Kang, Kazushige Mori, Katsuhiro Kojima, Junko Shimazaki
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Abstract
The purpose of the present invention is to provide a fungus-derived FADGDH that has a direct electron transfer ability. Provided is a fusion protein comprising a fungus-derived FADGDH or a mutant thereof and a cytochrome molecule connected to the N-terminus of the FADGDH or variant thereof.
Claims12
A fusion protein comprising:
- a variant of fungus-derived flavin adenine dinucleotide glucose dehydrogenase (FADGDH);
- and a cytochrome molecule linked to the N-terminus of the variant,
- wherein the variant comprises an amino acid sequence having one mutation selected from the group consisting of Glu346Lys, Asn430Lys, Asn430Arg, Thr498Lys, Glu504Lys, and Glu504Arg in the amino acid sequence of SEQ ID No:
- 4.
1 more element
Dependencies are inferred from the claim text.