Genetically modified cells that produce C6-C10 fatty acid derivatives
AssigneeCargill, Incorporated
InventorsHans H. Liao, Catherine Bradshaw Poor, Travis Robert Wolter, Michael Tai Man Louie, Erin Kathleen Marasco, Ana Negrete-Raymond
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Abstract
Genes encoding mutant 3-ketoacyl-CoA synthases are introduced into host cells. Certain of the mutants enhance the production of shorter-chain fatty acids and derivatives by the cell than do the wild-type (unmutated) enzymes. In other cases, the chain length is not significantly affected, but productivity is enhanced. In specific cases, both a shift toward lower chain length and higher productivity is seen. Cells producing the mutant 3-ketoacyl-CoA synthases are especially suitable for producing C6-C10 fatty acids and derivatives.
Claims6
A ketoacyl-CoA synthase having SEQ ID NO:
- 42 or being at least 80% identical to SEQ ID NO:
- 42, wherein the amino acid residue of the ketoacyl-CoA synthase that aligns with amino acid residue 186 of SEQ ID NO:
- 42 is isoleucine, leucine, methionine, cysteine, valine, glutamine, phenylalanine, aspartate, asparagine, or tyrosine.
Dependencies are inferred from the claim text.