Self-assembled hybrid hydrogels formed of a short aromatic peptide and an aromatic amino acid
AssigneeRamot at Tel-Aviv University Ltd.
InventorsLihi Adler-Abramovich, Rina Sevostianov, Irena Grigoriants, Ehud Gazit
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Abstract
Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic moieties being an end-capping modified aromatic dipeptide and at least another type of the aromatic moieties being an amine-modified halogenated aromatic amino acid, are provided. Also provided are processes of preparing the hybrid hydrogels and uses thereof.
Claims15
A hybrid hydrogel comprising a three-dimensional network of fibrillar nanostructures, at least a portion of said fibrillar nanostructures being formed of a plurality of aromatic moieties, said plurality of aromatic moieties comprising at least two different types of aromatic moieties, at least one type of said aromatic moieties being an N-terminus modified aromatic homodipeptide that comprises an aromatic end-capping moiety, and at least one type of said aromatic moieties being a halogenated aromatic amino acid that further comprises an aromatic moiety attached to the alpha amine of said amino acid,
- wherein the hybrid hydrogel is characterized by a storage modulus, G′, at a total concentration of the plurality of aromatic moieties of 0.5% by weight, higher by at least 2-folds, of a storage modulus of a hydrogel made of said N-terminus modified aromatic homodipeptide at a concentration of 0.5% by weight;
- and
- wherein a ratio of said N-terminus modified aromatic homodipeptide to said halogenated aromatic amino acid that further comprises an aromatic moiety attached to the alpha amine of said amino acid ranges from 3:1 to 1:3.
Dependencies are inferred from the claim text.