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US 12,122,851 B2Granted
PSMA imaging agents
AssigneeSiemens Medical Solutions USA, Inc.
InventorsEric Wang, Hartmuth C. Kolb, Anna Katrin Szardenings, Changhui Liu, Joseph C. Walsh, Gang Chen, Anjana Sinha, Dhanalakshmi Kasi, Chul Yu, Umesh B. Gangadharmath, Wei Zhang, Tieming Zhao, Vani P. Mocharla
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Abstract
Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
Claims11
A compound of Formula VII:
- and pharmaceutically acceptable salts and stereoisomers thereof,
- wherein:
- X1 is CH or N;
- X2 is CH or N;
- X22 is a protecting group;
- and
- X23 is (CH2)1-10—NH2 wherein at least one CH2 of (CH2) 1-10 is replaced by at least one selected from the group consisting of S, O, NH, heteroaryl, cycloalkyl and heterocycloalkyl.
4 more elements
Dependencies are inferred from the claim text.