Method for preparing biomaterial having selectively functionalized tyrosine, biomaterial having selectively functionalized tyrosine, and pharmaceutical composition containing same as active ingredient

A method for preparing a biomaterial to which a compound represented by Formula 2 is coupled, comprising a step of reacting a compound represented by Formula 1 and a biomaterial containing a tyrosine residue present on an outer surface of the biomaterial in an aqueous solution in the presence of a compound represented by Formula 3,

• wherein the compound represented by Formula 2 selectively binds to the tyrosine residue present on the outer surface of the biomaterial and the biomaterial is a protein:
• wherein in Formula 1, A is nonsubstituted or substituted C6-14 arylene or 5-20 membered nonsubstituted or substituted heteroarylene, wherein the substituted arylene and heteroarylene can be substituted with one or more selected from the group consisting of halogen, straight or branched C1-5 alkyl, straight or branched C1-5 alkoxy, ═O and —OH;
• L is any one selected from the group consisting of S, O, NR3, —NHC(═O)—, —C(═O)NH— and straight or branched C1-10 alkylene, or a combination thereof, and R3 is hydrogen or straight or branched C1-3 alkyl;
• and
• B is a compound for imparting functionality to a biomaterial;
• wherein in Formula 2, A, L and B are as defined in Formula 1 and the vertical line left of the sulfur atom indicates that the sulfur atom is bonded to the biomaterial;
• wherein in Formula 3, X is N;
• and
• Ra, Rb, Rc, Rd and Re are independently hydrogen or straight or branched C1-5 alkyl, Ra and Re can form 5-8 membered heterocycloalkenyl along with N to which they are attached, and Rb and RC can form 5-8 membered heterocycloalkyl along with N and X to which they are attached.