US 12,122,784 B2 · Preparation method for ecteinascidin compound and intermediate thereof

Abstract

The present invention provides a method for preparing an ecteinascidin compound and an intermediate thereof, and specifically provides a preparation method for a novel compound QT9, and a method of using QT9 to prepare an ecteinascidin compound. The method provided by the present invention has high reaction selectivity and high yield, the obtained compound is easy to purify, and defects in the prior art that multiple intermediates are oily substances, and the reaction selectivity is poor are solved. The method of the present invention is particularly applicable to industrial production.

Claims25

Dependent claims

A method for preparing compound QT9, comprising reacting compound QT10 with a hydroxyl protecting agent to obtain compound QT9:

wherein R1 of compound QT9 is a hydroxyl protecting group;
wherein, the compound QT10 is converted into compound QT9 under alkaline conditions using a base, and wherein the base is NaOH, KOH, NaH, LiOH, LiOCH3, Na2CO3, K2CO3 or a mixture thereof.

Dependencies are inferred from the claim text.

Facts

Application

17/283,012Filed 26 Aug 2019

Priority

CN 201910101895.01 Feb 2019

Published

US 2021/0355132 A118 Nov 2021

Granted

22 Oct 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07D 487/18
In which the condensed system contains three hetero rings: bridged systems
C07D 491/22
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one…
C07D 515/22
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring…: in…
Y02P 20/55
Improvements relating to the production of bulk chemicals: design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Preparation method for ecteinascidin compound and intermediate thereof

Life of this patent

Preparation method for ecteinascidin compound and intermediate thereof

Life of this patent

Abstract

Claims25