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US 12,122,765 B2Granted
Methods and intermediates for preparing therapeutic compounds
AssigneeGilead Sciences, Inc.
InventorsAnna Michelle Wagner, Scott Alan Wolckenhauer
Life of this patent
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Abstract
The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
Claims15
A process for preparing a compound of formula V-03-A:
- or a co-crystal, solvate, salt, or combination thereof, comprising:
- (a) combining a compound of formula V:
- or a co-crystal, solvate, salt, or combination thereof, wherein R is B(OH)2, B(OCH(Me)CH2C(Me)2O), B((1,2-di-O)C6H4), B(OCH2C(Me)2CH2O), BF3K, B(O2CCH2N(Me)CH2CO2), or B(OC(Me)2C(Me)2O), with a mesylating reagent, a base and a solvent to provide a compound of V-04-A:
- or a co-crystal, solvate, salt, or combination thereof;
- and
- (b) hydrolyzing the compound of formula V-04-A or a co-crystal, solvate, salt, or combination thereof, with a nucleophilic reagent, a solvent, and optionally, a phase transfer catalyst to provide the compound of formula V-03-A or a co-crystal, solvate, salt, or combination thereof.
3 more elements
Dependencies are inferred from the claim text.